| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Determination of βS haplotypes in patients with sickle-cell anemia in the state of Rio Grande do Norte, Brazil
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| Autores: |
Cabral,Cynthia Hatsue Kitayama
Serafim,Édvis Santos Soares
Medeiros,Waleska Rayane Dantas Bezerra de
Fernandes,Thales Allyrio Araújo de Medeiros
Kimura,Elza Miyuki
Costa,Fernando Ferreira
Sonati,Maria de Fátima
Rebecchi,Ivanise Marina Moretti
Medeiros,Tereza Maria Dantas de
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| Data: |
2011-01-01
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| Ano: |
2011
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| Palavras-chave: |
Haplotypes
Β-globin
Sickle-cell anemia
Brazilian population
S hemoglobin
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| Resumo: |
βS haplotypes were studied in 47 non-related patients with sickle-cell anemia from the state of Rio Grande do Norte, Brazil. Molecular analysis was conducted by PCR/RFLP using restriction endonucleases XmnI, HindIII, HincII and HinfI to analyze six polymorphic sites from the beta cluster. Twenty-seven patients (57.5%) were identified with genotype CAR/CAR, 9 (19.1%) CAR/BEN, 6 (12.8%) CAR/CAM, 1 (2.1%) BEN/BEN, 2 (4.3%) CAR/Atp, 1 (2.1%) BEN/Atp and 1 (2.1%) with genotype Atp/Atp. The greater frequency of Cameroon haplotypes compared to other Brazilian states suggests the existence of a peculiarity of African origin in the state of Rio Grande do Norte.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000300009
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572011005000027
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.34 n.3 2011
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| Direitos: |
info:eu-repo/semantics/openAccess
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